Beyond Monoamines-Novel Targets for Treatment-Resistant Depression: A Comprehensive Review

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Beyond Monoamines-Novel Targets for Treatment-Resistant Depression: A Comprehensive Review

Major depressive disorder (MDD) is a leading cause of disability worldwide. Current first line therapies target modulation of the monoamine system. A large variety of agents are currently available that effectively alter monoamine levels; however, approximately one third of MDD patients remain treatment refractory after adequate trials of multiple monoamine based therapies. Therefore, patients ...

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ژورنال

عنوان ژورنال: Current Neuropharmacology

سال: 2015

ISSN: 1570-159X

DOI: 10.2174/1570159x13666150630175044